用丝裂霉素C作青光眼辅助药的研究进展

Mitomycin C as an adjuvant in glaucoma surgery

青光眼滤过术后纤维细胞的增殖和胶原的产生是引起巩膜伤口瘢痕化导致滤过泡失败的主要原因。尤其是年轻人、无晶体眼、眼前节新生血管形成、炎症、以前失败过的滤过术等危险因素更容易降低手术疗效。实验和临床研究证实,术中单独一次应用抗代谢药丝裂霉素C能抑制成纤维细胞增殖,阻止巩膜伤口纤维化,增加手术预后差的眼的滤过术成功率。它所引起的副作用,如角膜上皮缺损比较低,给药方式也较好。但它在眼部抗纤维化治疗中的作用尚需进一步研究。

The most common cause of glaucoma filtration surgery failure is cicatrization secondary to fibroblast proliferation and of collagen. The high-risk factors for filtration failure include young age, aphakia, inflammation, neovascularization, and previous failure of filtration operation. Studies have shown beneficial effects of a single dose intraoperative mitomycin C,an antimetabolite, in inhibiting fibroblast proliferation and slceral wound cicatrization, thereby promoting success in eyes of poor surgical prognosis. Corneal complications have been minor.