尼群地平对大鼠糖尿病性心肌病的有益作用

Beneficial effects of nitrendipine on diabetic cardiomyopaty in rats

观察尼群地子(Nit)对实验性糖尿病大鼠心肌舒缩功能、心肌琥珀酸脱氢酶和细胞色素氧化酶活性的影响。结果表明,糖尿病发生4周时大鼠心室舒张功能发生改变,8周时心室舒张和收缩功能均明显受累。Nit处理可改善糖尿病大鼠心肌舒缩功能。糖尿病大鼠心肌琥珀酸脱氢酶和细胞色素氧化酶活性比对照组明显下降,接受Nit处理后可明显恢复以上酶的活性。提示Nit处理对大鼠糖尿病性心肌病有一定有益作用。

The effects of nitrendipine (Nit) on myocardial contractility, myocardial succinate de-hydrogenase (SDH) and cytochrome oxidase (CCO) activities in streptozotocin (65mg/kg) diabetic rats were studied. Four weeks after the induction of diabetes, the rats were treated with Nit (30mg ?kg -2/day) for 4 weeks. The results showed that ventricular diastolic function was affected after 4 weeks of diabetes, and both ventricular diastolic and systolic functions were obviously involved after 8 weeks. These changes were significantly improved in diabetic rats receiving Nit treatment. The myocardial SDH and CCO activities in diabetic animals were markedly lower as compared to controls. The attenuation of these enzyme activities in diabetic rats was significantly reversed by administration of Nit. These findings suggest that Nit treatment may exhibit some beneficial effects on diabetic cardiomyopathy.