新生儿脐血T细胞亚群分布特点

CHARACTERISTIC OF T CELL SUBSETS IN UMBILICAL CORD BLOOD FROM NORMAL NEW-BORN INFANTS

应用OKT系列单克隆抗体对45例足月新生儿脐血和30例2～7岁健康儿童外周血T细胞亚群进行检测,发现脐血OKT_3^+细胞百分率和OKT_4^+/OKT_8^+比值显著低于儿童外周血,OKT_8^+、OKT_(10)^+和OKT_(48)^(++)细胞百分率均显著高于儿童外周血,而OKT_4^+细胞百分率两组间无差异。男、女间脐血T细胞及亚群均无明显差异。结果表明脐血中T细胞表面抗原标记和细胞亚群发育均不成熟。

T cell subsets in umbilical cord blood from 45 normal new- born infants and in peripheral blood from 30 normal children were dete- cted using OKT monoclonal antibodies. The mean percentage of OKT_3^+ cells and the ratio of OKT_4^+ cells to OKT_8^+ cells in umbilical cord blood were significantly lower than those in peripheral blood of children. The mean percentages of OKT_8、OKT_(10) and OKT_4^+ cells in umbilical cord blood were all significantly higher than those in peripberal blood of children. But the mean percentage of OKT_4^+ cells between two groups was no difference. T lymphocytes and subsets in umbilical cord blood between male and female were also no cifference. The resuit indicated that the development of antigenitic marks on T cell surface and T cell subsets in umbilical cord blood from normal new-born infants was immature.