摘要
应用卡托普利(Cap)治疗难治性心衰37例(男 31例,女 6例),年龄 53～79岁,平均63岁。冠心病17例,高心病14例,扩张型心肌病5例,肺心病1例。心功能Ⅲ级9例,Ⅳ级28例。Ccp25～75 mg/d,平均 42.65 mg/d,治疗 2.5～4 d(平均 3.6 d)。心功能显著改善达 Ⅱ级者 20例(54.1％),改善Ⅰ级者14例(37.8％),无效2例,停止观察1例,总有效率91.9％。用药前及治疗后10～14 d,心搏出量、心输出量、射血分数均显著增加,差异非常显著(P<0.01),肺毛细血管楔压、左室舒张期末压明显下降(P<0.01)。用Cap 治疗心力衰竭剂量宜偏小,除注意防止低血压外,一般无严重反应。
37 cases of refractory heart failure patients were treated by captopril,a an giotensin-converting enzyme inhibitor (ACEI). Of these patients 13 were men and 16 wom en with age ranging from 53 to 79 yr (mean = 63 yr) ,including 17 cases of CAD,14 cases of hypertensine heart disease, 5 cases of dilated cardionyopathy and one case of cor pul monale. 9 patients fell into heart function class Ⅲ,28 patient class IV. The patients were given captopril 25-75 mg daily (mean dose 42. 65.mg/day). 20 patients(54%)showed a significant improvement of two -grade of heart function (37%). Two patients failed to re spond to the treatment, with total effective rate of 91%, 10-14 days after treatment(P< CO,EF increased significantly (P<0. 01). PCWP and LVEDP decreased substantially (P< 0. 01). When treating heart failure with cap topril, small dosage is recommended. Except that care should be taken to avoid hypotension no other side-effects is found. Captopril is a. safe ane satisfactory drug for treatment of heart failure.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
1993年第S2期81-83,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
