摘要
以枳实煎剂对其抑制小鼠离体小肠平滑肌收缩的机理进行了研究。枳实能非竞争性拮抗乙酰胆碱(Ach)和组织胺(His)对小肠平滑肌的收缩作用;与肾上腺素(Adr)不同,枳实的松弛平滑肌的作用不能被—受体阻断剂哌唑嗪和β-受体阻断剂普奈洛尔所对抗。枳实与维拉帕米(Ver)相似可使BaCl_2收缩平滑肌的量效曲线平行右移。实验结果提示,枳实可能是通过影响Ca^(2+)
Citrus Aurantium L (CA-L) inhibited both Ach-induced and His-induced contraction of isolated mouse intestine no-competitively. Different from tha of Adrenaline, the inhibitory effect of CA-L on isolated intestine was not antagonized by Prazosin and Propranolol respectively. CA-L, si milar to Verapamil, inhibited the contraction induced by BaCl_2 and shift the concentration-response curve parallelly to the right. These above show that CA-L has no any action on receptors and might possesses calcium antagonistic effect on isolated mouse intestine, muscle.
出处
《中国医科大学学报》
CAS
CSCD
1993年第S1期49-53,共5页
Journal of China Medical University
基金
国家自然科学基金
关键词
枳实
小肠平滑肌
钙
Citrus Aurantium L
isolated intestine
calcium antagonism
