卡介苗素注射调节反复呼吸道感染患儿T淋巴细胞亚群的研究

STUDY ON INJECTION OF EXTRA-BCG ADJUSTISTING T LYMPHOCYTE SUBPOPULATION OF CHILDREN WITH REPEATED RESPIRATORY TRACT INFECTION

测定48例反复呼吸道感染患儿外周血T淋巴细胞亚群,以20例同龄正常儿为对照组观察。结果表明:病例组全T细胞(CD_3),T辅助细胞/T诱导细胞(CD_4)、CD_4/CD_8值均明显低下;T抑制细胞/T细胞毒细胞(CD_8)值增高。提示反复呼吸道感染患儿细胞免疫功能低下,免疫调节功能紊乱。对其中31例注射卡介苗素治疗后,CD_3、CD_4、CD_4/CD_8均有明显升高,CD_3明显降低。

T lymphocyte subpopulation in peripheral blood of 48 children with repeated respiratory tract infection were investigated. CD_3, CD_4, CD_4/CD_3 were significantly decreased, and CD_8 were increased than that of nor mal children. Extra-BCG was injeced in thirty one children and three months later, T lymphocyte subpopulation were investigated again, CD_3, CD_4, CD_4 CD_8 were significantly increased but CD_8 were clearly reduced. These findings demonstrated that extra-BCG has the function of improving cell immunity disorder.