十二指肠球炎与胃泌酸量及血清胃泌素、血清胰泌素关系的探讨

DISCUSSION OF THE RELATION BETWEEN DUODENITIS AND SERUM GASTRIN,SERUM SECRETIN AND GASTRIC ACID LEVEL

检测了11例十二指肠球炎患者的胃泌酸量及血清胃泌素、血清胰泌素的含量。并以健康人及十二指肠球部溃疡患者对照。结果显示:十二指肠球炎组的PAO及PAO的均值明显高于健康对照组(P<0.01),而低于十二指肠球部溃疡组(P<0.05)。十二指肠球炎组的血清胃泌素及胰泌素的含量均值明显高于健康对照组(P<0.01)及十二指肠球部溃疡组(P<0.05)。其机制可能是胃泌素增高—胃泌酸量增加—刺激S细胞分泌胰泌素增高的结果。

The level of serum gastrin, serum secretin and gastric acid were measured in 11 patients with duodenitis and in the control groups, the control groups included healthy control and duodenal ulcer control. Results showed that (1) mean BAO and PAO in duodenitis group were much higher than that in healthy group (P<0.05) , but lower than that in duodenal ulcer group (P<0.05), (2) mean fasting serum gastrin and secretin duodenitis group were much higher than that in healthy group (P<0.01) and duodenal ulcer group (P<0.05) . The mechanism may be that enhanced serum gastrin resulted in increased secretion of gastric acid, then S cells were stimulated to ecrete secretin to higher level.