期刊文献+

孕大鼠胎盘药物代谢酶以及MeP对酶活性影响的研究

下载PDF
导出
摘要 近几十年来,越来越多的证据表明胎盘对某些前致癌物/前致突变物如苯并(a)芘等有代谢活化的能力,一些外源物经胎盘转化后对胎仔有致毒作用。目前,胎盘代谢酶在催化代谢外源物的地位及其意义尚未完全阐明。
出处 《毒理学杂志》 CAS CSCD 1993年第S1期193-196,共4页 Journal of Toxicology
  • 相关文献

参考文献8

  • 1William M. Draper,Joseph C. Street.Drift from a commercial, aerial application of methyl and ethyl parathion: An estimation of potential human exposure[J]. Bulletin of Environmental Contamination and Toxicology . 1981 (1)
  • 2Pelkonen O and Pasanen M.Enzymology and regulation of xenobiote and steroid metabolism in placenta. Biochemical Society Transactions . 1984
  • 3Blanck A,et al.Biotransformation of benzo (a) pyrene and 7-ethoxy rosorufin and heme-staining proteins in microsomes from human fetal liver and placenta. Biochemical Pharmacology . 1983
  • 4Tanimura T,et al.Embryotoxicity of acute exposure to methyl paration in rats and mice. Archives of Environmental Health . 1967
  • 5Jones A H,et al.Bioactivation of precarcinogens to mutagens in human fetal and placental tissues. Life Sciences . 1977
  • 6Namkung M J and Juchau M R.On the capacity of human placental enzymes to catalyse the formation of diols from benzo(a)pyrene. Toxicology and Applied Pharmacology . 1980
  • 7Bogdan D P and Juchau M R.Characteristics of induced benzo (a) pyrene hydroxylase activity in the rat fetoplacental unit. European Journal of Pharmacology . 1970
  • 8Thomas P E,et al.Introduction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochrome P450e and P450d, By structurally diverse xenobiotics. Journal of Biological Chemistry . 1983

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部