夏季小儿急性肠炎时肠道双歧杆菌的动态变化

Dynamic Fluctuation of Bifidobacteria in Children Suffering from Acute Infectious Diarrhea in Summer

本文测定了30例夏季小儿急性细菌性腹泻患儿发病早期粪便中双歧杆菌的数量,并与15例健康儿作了对照。结果提示急性细菌性腹泻时双歧杆菌数量明显低于健康儿。从上述肠炎患儿中随机选取10例,分别在发病早期、好转期、痊愈时及痊愈后一周做了双歧杆菌的动态定量分析,发现2例在病程中逐渐减少,8例在粪便稀释10倍时亦未检出,10例患儿在愈后一周时双歧杆菌均低于健康小儿。对双歧杆菌的生理作用进行了讨论。

Bifidobacteria cultivated from the faeces of 30 children with acute infectious diarrhea in summer were studied. The logarithmic value of bifidobacteria in one gram of wet faeces in the early stage of diarrhea was lower than that of the healthy children. In addition, We observed dynamicly the numerical values of bifidbacteria in 10 cases at the early stage of diarrhea, the period of improvement time of recovery and on the seventh day after revovery, the viable count decreased progressively in 2 cases, The Bifidobacteria was not detected in 10^(-1) dilution of faecal material throughout the illness in 8 cases with persistant use of certain antibiotics and the viable number was still under the normal level as compared with those healthy children by the seventh day after revovery in all cases. At this time, it was noted that the attendant physician used to continue prescribing certain antibiotics to the pationts for a short period 2—3 days after clinical recovery. The biological function and significance of bifidobacteria were discussed.