抗生素对新生儿肠道菌群影响的初步研究

Preliminary study of Influence of Antibiotics on the Intestinal Flora of Neonates

本文采用肠道菌群定量定性分析法,利用用药前后的自身对照,研究了静脉应用氨苄青霉素加青霉素的先锋铋对30例足月、患非肠道感染性疾病的新生儿肠道菌群的干扰,结果表明:两组抗生素均造成新生儿肠道菌群紊乱。氨苄青霉素加青霉素使肠杆菌科细菌明显增加,其他细菌无显著变化,优势菌由乳杆菌变为肠杆菌,腹泻率26.7％,菌群失调程度Ⅰ°—Ⅱ°;先锋铋使正常肠菌群成员显著减少,仅酵母菌过盛繁殖,成为优势菌,腹泻率53.3％,菌群失调程度多为Ⅰ°—Ⅱ°。部分Ⅲ°。

To evaluate the effects of parenteral ampicillin (ABPC)plus penicillin (PC) and cefoperazone (CPZ)on fecal flora of the neonates of infections diseases other than the digestive diseases, fecal specimen obtained from 30 fullters,normal delivered neonates before and during an- tibacterial theray were cultured quantitatively and qualitatively. The results showed that ABPC+PC and CPZ all induced to the dysbacteriosis of neonates. ABPC+PC caused the increase of Enterobacteriaceae after 3 to 7 days of administration of the antibiotics, but no significant changes occured in other members of fecal flora such as Lactobacillus, bifidobacterium, Enterococcus and Staphylococcus. The predominant bacteria gradually become Enterobacteriaceae from Lactobacillus.The rate of diarrhea was 26.7%. The degree of dysbacteriosis was from Ⅰ °to Ⅱ°,There was significant suppression or suppression to undetectable levels in investigated fecal bacteria of feces after CPZ therapy,and there was acquisition or an increase in accounts of yeast, So that yeast became the most numerous fecal microorganisms. The rate of diarrhe was 53. 30％. The degree of dysbacteriosis was mostly from Ⅰ°to Ⅱ°, partly Ⅲ°.So influence of CPZ on fecal flora of neonates was more remarkble than those of ABPC+PC. We must select the most suitable antibiotics in clinical practice of neonates, which could help patients overcome their infection.