烧伤肠球菌肠源性感染

Gut Origin Enterococci Infection after Thermal Injury

肠球菌是宿主肠道中正常G^+球菌,目前已成为医源性感染的重要致病菌。临床上有30％肠球菌感染患者感染源不明,拟肠道来源可能性最大。本文给小鼠肌注灭滴灵3日,造成动物肠系膜淋巴结(MLN)肠球菌的感染率为40％;肌注灭滴灵加口服链霉素,MLN的感染率上升为90％,肝脾内脏中的感染率为83％;联合使用上述抗生素合并25％体表面积烧伤,动物发生致死性肠球菌性肠源性感染,动物诸内脏中肠球菌感染的检出率均高达100％。本研究证明肠球菌感染可以是肠源性的。

In recent years, enterococci have emerged as significant nosocomial pathogens even they are part of the normal bowal flora of humans.Thirty percent of the patients from whom enterococci are isolated who often have an undefined focus of infection,gut has been thought to be the most possible source of the infection. 40％ of mice treated with metronidazole were colonized by enterococci in their mesenteric lymph nodes (MLN);translocating enterococci were recovered from the MLN of the 90％ mice given metronidazole and streptomycin;using with two kinds of antibiotics plus 25% area of burn injury,we found that enterccoci were recovered from the multiple organs in 100% of animal.These data indicate that enterococci can translocate out of the intestinal trancts after treated with antibiotics plus thermal injury to promote the gut origin infection.