参附柴抗生素合用对感染性休克病人氧自由基有关参数的影响

Effect of combined administration of Shen-FuChai Antibiotics on the parameters associated with oxygen free radical in patients with septic shock/

本研究观察了感染性休克病人氧自由基有关参数的变化和参附柴抗生素合用(SA)对此的抑制作用。结果表明:感染性休克时红细胞超氧化物歧化酶(SOD),全血谷胱甘肽过氧化物酶(DSH—PX)活性降低,血浆丙二醛(MDA)、血浆游离血红蛋白(pHb)含量和血浆β—葡萄糖醛酸酶(β—GC)活性升高;SA能抑制这些参数的变化,对阻止休克时SOD活性降低和β—GC、pHb水平升高SA有优于抗生素地塞米松合用的趋势。提示SA具有保护抗氧化酶活性、抑制脂质过氧化和稳定细胞膜作用,这可能是SA抗感染性休克的重要机理之一。

In this study,the change of the parameters associated with oxygen free radical and the inhibitory effect of combinedadministration of Shen- Fu- Chai- Antibiotids (SA),were observed in patients with septic shock.The results demonstrated that the decrease of the activities in both superoxde dismutase(SOD)and glutathionine peroxi-dase(GSH-PX)in red blood cell and the increase of the contents of plasma free hemoglobin (PHb) and plasma malondialdehyde (MDA) and the activity of β- giy-curonidase(β-GC) occurred in septic shock.SA inhibited the change of the parameters mentioned above and has better effect than Antibiotics- Dexamethason combined therapy in inhibiting the changes of certain parameters such as SOD,β-GC,and PHb.Hence,these results suggest that SA diminished the decrease of the antioxdase activities and inhibited lipid peroxide and stabilized cell membrane.This may be one of the principal mechanisms of the beneficial effect of SA in the treetment of septic shock.