无机汞对鼠胎盘转运功能的影响

PLACENTAL TRANSFER OF INORGANIC MERCURY IN RAT

通过母鼠,胎盘和胎鼠血汞浓度测定和胎盘病理学检查,进一步研究无机汞的胎盘转运功能。将妊娠大鼠随机分为四组,皮下注射HgCl_2溶液,剂量为0.6mg、0.3mg、0.15mg/kg和蒸馏水。结果表明,HgCl_2各剂量组的母鼠、胎盘和胎鼠血汞浓度呈现明显的剂量一反应关系,两两比较有显著正相关。胎盘病理改变表现滋养层和血窦部组织被破坏,证明氯化汞有胎盘转运功能。

To clearify the maternal-fetal transfer of inorganic mercury across the placenta, concentration of mercury in maternal blood of rat, placental blood and fetal blood as well as pathological changes of placental tissue were determined. The pregnant rats were divided into 4 experimental groups randomly. Mercuric chloride (0.15, 0.30, 0.60mg/Kg)and distilled water were injected into the pregnant rats daily within 7-16d. the results showed that there were positive correlation between the concentration of mercuric chloride in maternal and placental (or maternal and fetal, placental and fetal) blood in every dose group. A clear dose-response relationship was indicated in every samples. The pathological changes showed the struture of trophoblast and blood sinus were destructed. It may be concluetd that mercuric chloride reaches the transplacental route.