ROLE OF REACTIVE OXYGEN IN MOUSE EPIDERMAL TUMOR PROMOTION

Generation of reactive oxygen(RO),has been proposedas an important event in mouse epidermal tumor promo-tion by 12-O-tetradecanoylphorbol-13-acetate (TPA). We investigate the role of RO in the promotion ofneoplastic transformation of JB6 mouse epidermal cellsby TPA using a battery of RO scavengers:CuZn-superoxide dismutase (CuZn-SOD),catalase。