CHEMICAL“CARCINOGENS”,AS MODULATORS OF INTER-CELLULAR COMMUNICATION,ARE MITOGENS,NOT MUTAGENS.

Although mutations clearly play a role in themulti-stage process of carcinogenesis,a challengewll be made to the paradigm that most chemical"carcinogens" act via mutagenic activity("carcinogens as mutagens").Control ofproliferation and differentiation within andbetween tissues is mediated by