STUDY OF THE RELATIONSHIP BETWEEN THE HEPATOTOXICITY AND FREE RADICAL INDUCED BY 1,1,2-TRICHLOROETHANE AND 1,1,1-TRICHLOROETHANE IN RAT LIANG-FU XIA,DEPARTMENT OF TOXICOLOGY,SECOND MILITARY MEDICAL UNIVERSITY,SHANGHAI,CHINA.

1,1,2-trichloroethane(1,1,2-TCE) and 1,1,1-trichloro-ethane(1,1,1-TCE) were administered to rats to evaluatethe toxic effects on the rat liver.During whole animalstest the serum enzymes were assayed at 8 hr,12 hr,24 hr,36 hr,48 hr and 72 hr after the rat receiving 1,1,2-TCEand 1,1,1-TCE.The results showed that 1,1,2-TCE let tomuch higher values for SGPT,SSDH and SGDH than 1,1,1-TCEdid,especially at 24 hr after administration.At