甲胎蛋白异质体对原发性肝细胞癌的诊断价值

THE CLINICAL SIGNIFICANCF OF THE DETERMINATION OF ALPHA. FETOPROTEIN SUBFRACTION IN PRIMARY HEPATIC CANCER

通过扁豆凝集素亲和双向免疫电泳,对47例原发性肝细胞癌(PHC),40例良性肝病,6例转移性肝癌血清AFP异质体进行研究,发现PHC患者血清扁豆凝集素结合型AFP为43.298±22.4%,明显高于良性肝病患者(10.35±17.053%)及转移性肝癌患者(4.167±6.646%)。以该值大于25%为诊断肝癌标准,则阳性率为82.98%特异性为90%。在14例AFP为阴性的PHC患者中,有10例该值大于25%,其阳性率为71.43%。对PHC患者行肝动脉栓塞术后其扁豆凝集素结合型AFP降低,故可用其做为观察疗效的指标。

Alpha-fetoprotein (AFP) subfraction were studied in 93 sera including 47patients with primary hepatic cancer (PHC), 40 hepatic benign disease and 6from Patientts with hepatic metastasis of gastric cancer. Subfraction of AFp wascarried out by lentil lectin (LCA) crossed-line affinity immunoelectrophoresisThe percentage of AFP-R-L was significantly higher in 47 patients with pri-mary hepatic cancer (43.298±22.4%) than in 40 patients with hepatic beni-gn disease (10.53±17.053%) and in 6 patients with hepatic metastasis ofgastric cancer (4.16±6.646%) (P<0.01). If The percentage of higher than25% AFP-R-L is suggested as the diagnostic criterion of PHC, then thepositive rate is 82.98%. Among 14 patients of PHC with AFP less than 50ng/ml, the positive rate is still 71.423%. In addition, AFP-R-L may be usedas a parameter in monitoring the therapeu tic effect of the treatment inpatients with PHC.