强啡肽(DYN)对人胎盘绒毛组织促性腺素分泌的影响

EFFECT OF DYN ON hCG RELEASE FROM HUMAN PLACENTA VILLI OF EARLY PREGNANCY (6-10 WEEKS)

用胎盘绒毛组织体外孵育法(无血清培液)研究了强啡肽对妊娠6～10周人胎盘绒毛组织分泌促性腺素的影响.结果表明,当DYN浓度为10^(-9)mol/L,与对照组相比,有明显的刺激作用(P<0.05);浓度为10^(-10)mol/L,刺激作用最强(p<0.001).DYN可能在胎盘绒毛组织分泌hCG中起重要作用.

The effect of DYN on hCG release from human placenta villi of early pregnancy (6-10 weeks) was studied in vitro. Placenta villi were incubated in serum-free McCoy's 5a medium. The results show that DYN stimulated hCG release from placenta villi. The hCG secretion increased and reached a maximum level at a dose of 10^(-10)mol/L (p<0.001), the dose of 10^(-9)mol/L also had a significant stimulating effect (p<0.05), but higher concentration of DYN could not augment hCG release markedly. It's concluded that DYN may play an important role in regulating hCG release.