高胆红素血症新生儿血清β_2微球蛋白含量的观察

Observation of serum β_2-Microglobuline concentration in neonates with hyperbilirubinemia

用日产MEB-332型微胆测定仪及放免测定法测定高胆红素血症新生儿12例和非高胆红素血症新生儿血清β_2-MG浓度。以观察高胆红素血症对肾脏的可能影响。结果发现生后第4天血清β_2-MG浓度高胆组为4.42±0.51mg/L,非高胆对照组为3.95±0.37mg/L,两组比较无明显统计学差异;但生后第7天血清β_2-MG浓度高胆组为4.77±0.64mg/L,非高胆对照组为3.56±0.43mg/L,两组间具有显著统计学差异,提示高胆红素血症可能会引起肾脏损伤;而这种对肾脏的影响可能与高胆红素血症的持续时间有关。

In this study, serum levels of β_2-Miaine (Sβ_2-MG)weredetermined in 12 neonates sith hy perbilirubinemia and 39 normal conttrols by radioimmunoassy(RiA). It was found that Sβ_2-MG con centrationin, the 4th day of life, neonatalneonatal hyperbilirubinemia was 4.42±0.51 mg/L, normal controls was 3.95±0.37mg/L, thd comparison between the two group being p>0.05, but in the 7th day of life it was higher in the neonatal hyperbilirubinemia (4.77±0.64mg/L)than the normal controls (3.56±0.43mg/L)(p<0.01). this study suggest that neonatal hyperbilirubinemia can influence the renal function.