T小淋巴细胞性淋巴瘤/白血病形态学和免疫表型的特征

T—small lymphocytic lymphoma/leukema: A study of morphological and immunophotypical characteristics

本文用形态学、酶组化及免疫学包括单克隆抗体、免疫组化法研究10例T小淋巴细胞性淋巴瘤。7例原发于淋巴结及扁桃体,形态上依据核的外形分为圆型和曲核型,免疫表型Leu,7例均(+),Leu3a 5例(+),Leu2a均为(—)。3例为OKT3(+),OKT8(+),OKT4(—),OKT6(—),OKB7(—)。讨论了此型淋巴瘤的临床和病理特征、命名、分型及我们对分型的新建议。其中1例皮肤淋巴瘤的形态变化,可能说明T细胞的形形态转化。

Ten patients diagnosed as T-small lymphocytic lymphoma/leukemia(T-SLL) were studied by morphology, enzyme-histochemistry and immunocytochemistry, 5 had initial lestions in lymph nodes,2 in tonsil and 1 in nose, in nasopharynx and on skin, respectively. Morphologically,the tumours were divided into round or convoluted nuclear type based on tumour nuclear outline. Immunopheno typically,the tumour cells showed Leul(+) (CD5+ ) in 7 cases, Leu3(+)(CD4+) in 5 cases,and Leu 2(-)(CD8-)in 7 cases,OKT3(+) (CD3 + ),OKT4(-)(CD4+),OKT8(+)(CD8+),OKT6(-)(CDl-),and OKB7(-) in 3 cases,respectively,In three cases of the OKT8+(CD8+)SLL, the morphologic features differ from the usual CD8(+) CLL with azurophilic granules. Heterogeneity of morphology in a case with cutaneous T-small lymphocytic lymphoma was seen. This paper discusses the clinicopathological features or this lymphoma/Leukemia.