乳腺髓样癌、浸润性导管癌、小管癌和腺样囊性癌的超微结构对比分析

Ultrastructural Comparative Analyses of Medullary, Infiltrating Ductal,Tubular and Adenocystic Breast Carcinomas

对临床上较为常见的乳腺髓样癌(medullary carcinoma,MC)、浸润性导管癌(infiltrating ductalcarcinoma,IDC)和较为少见的小管癌(tubular carcinoma,TC)、腺样囊性癌(adenoid cystic carcinoma,ACC)的超微结构进行对比分析。发现:基板和肌上皮在浸润性导管癌及腺样囊性癌中明显可见,在另二型中似乎已消失;乳腺癌及其转移灶中均明显存在胞质内微囊(intracytoplasmic cyst,ICC),与良性病变有显著差异(P<0.01),认为它在良、恶性病变鉴别及原发部位不明转移灶的鉴别诊断中有一定价值。对四型乳腺癌的组织发生、基板和肌上皮存在与预后的关系、A型病毒样颗粒及蚓条小体出现的意义进行了讨论。

Ultrastructural comparative studies on medullary,infiltrating ductal, tubular and adenocystic carcinomas of the human breast were presented. The results discovered that basal laminae and myoepithelial cells, while prominent in the infiltrating ductal and adenocystic carcinomas,were almost absent in the other two patterns. Intracytoplasmic cysts (ICC) were quite obvious existed in four patterns of breast neoplasm, and in metastatic focuses of medullary and infiltrating ductal carcinomas. The frequency of ICC in breast cancers were significantly higher than that in benign breast lesions (P<0. 01),they might be helpful in the differential diagnosis between benign and malignant breast diseases, and find primary focus for metastatic carcinomas. The relationships between the presence of basal laminae as well as myoepithelium in breast carcinomas and prognosis, the significance that A type virus-like granules and vermicular bodies presented in breast carcinomas have been discussed.