脾切除对红细胞内谷胱甘肽含量的影响

The Influence of Splenectomy to Glutathione of Red Blood Cells

脾切除后25条家犬红细胞内谷胱甘肽含量明显升高,术后30天达高峰,术后45天渐渐下降。红细胞脆性降低,比容变化不大。与对照组比较,均有显著差异。本实验提示:用脾切除治疗溶血性贫血性疾病远期效果不佳,可能与GSH变化有关。为巩固疗效,脾切除后应用外源性GSH来辅助治疗。

The concentration of glutathione of red cells were determined by 25 dogs for splenectomy and 20 dogs for comparison. Glutathione of RBC were determined after seperately 15 day, 30 days,45 days, 60 days of the splenectomy. At the 30th day glutathione concentration of RBC reached the highest,after that it began to decrease. The function of spleen is not only filterfaction of RBC,but also,perhaps, the transformation of the pathway membrance,whice should be disscussed and studied later. Further supposal,that some hemolytic diseases treated by splenectomy acquired the resultless in far could relative to GSH and auiliary treat with GSH for consolidating the effectes.