裂隙灯致视网膜损伤的眼底荧光血管造影观察

AN EXPERIMENTAL STUDY ON RETINA INJURY INDUCED BY SLIT LAMP

作者作国产裂隙灯对3只恒河猴双眼黄斑周围视网膜共36个部位进行随机持续光照,视网膜照度为226.8mW/cm^2。照射时间分别为30,45,60,90,105,120,150,180min。通过眼底镜,荧光血管造影对光照前及光照后即刻到2个月的视网膜变化进行观察。当持续光照达120min以上时出现视网膜损伤。光照后不同时间使视网膜损伤的眼底改变不同。作者提出,裂隙灯使用的相对安全时间阈值为98min,并提出多部位投照方法。

Thirty—six paramacular sites of six eyes in three rhesus monkeys (Macaca mulatto) were exposured to the beam of a Suzhou made slit lamp. The irradiance on retina was 226.8 mW/cm^2. The exposure time is 30, 45, 60, 90, 105, 120, 150, 180 minutes respectivly. The fundus were examined before exposure, soon after exposure, threedays, two weeks, one month and two months after exposure with funduscopy and fluorescein angiography. The typical retina lisions would be seen after more than 120 minutes exposure. In different follow—up period after exposure, the lesions had different feature. The relative safty threshold exposure time is 98 minutes by statisttic calculate. The method for exposing multiple sites of single eye was described.