摘要
本实验用结扎大白鼠大脑中动脉及颈总动脉制备的急性局灶性脑梗塞模型,研究了小檗胺对脑缺血的保护作用,并与已知的钙拮抗剂尼莫地平进行比较。结果显示,小檗胺不仅显著减小梗塞组织 Ca++增加的幅度且可明显缩小皮层梗塞面积;其作用与尼莫地平相似,但弱于尼莫地平。我们未发现脑缺血时 Mg++含量的改变,小檗胺对 Mg++含量也无影响。
The protective effect of berbamine on acuteregional cerebral ischemia in rats was studied andcompared the effect of well known Ca^(++)antagonistnimodipine.The regional cerebral ischemia modelwas madeby ligating the right middle cerebralartery and the right common carotid artery.It isshowed that berbamine has similar effect asnimodipine but with less potency.It can not onlysignificantly reduce the amount of calciumaccumulated in ischemic tissue but also significansignificantly decrease the area of infarctionThere are no difference of magnesium contentsbetween control group and ischemic group
出处
《中华神经外科杂志》
CSCD
北大核心
1990年第S1期12-14,88,共4页
Chinese Journal of Neurosurgery
