STUDIES ON THE CONFORMATIONS OF SUBEROGORGIN AND ITS METHYL ESTER BY MNDO METHOD

STUDIES ON THE CONFORMATIONS OF SUBEROGORGIN AND ITS METHYL ESTER BY MNDO METHOD

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摘要 The novel reversible anticholinesterase (anti-ChE) agent suberogorgin (S) has potent anti-ChE activity and lower toxicity and is possible to become the new drug for the treatment of senile dementia and amnesia. It has been found that the carboxyl, carbonyl groups and double bond of S are the main groups to produce the biological activity in our previous studies on its structure-activity relationships (SAR). In order to explore the relationship between the conformers and biological activity, we have studied the conformational characteris-

作者陈邦华焦克芳纪庆娥宋鸿锵

机构地区 Institute of Pharmacology and Toxicology

出处《Chinese Science Bulletin》 SCIE EI CAS 1990年第23期2008-2011,共4页

基金 Project supported by the National Natural Science Foundation of China.

关键词 suberogorgin CONFORMATION MNDO method. SUPEROGORGIN CONFORMATION MNDO METHOD

分类号 N [自然科学总论]

引文网络
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Chinese Science Bulletin

1990年第23期

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STUDIES ON THE CONFORMATIONS OF SUBEROGORGIN AND ITS METHYL ESTER BY MNDO METHOD

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