苯由母体—胎转运及其对胎仔影响的实验研究

THE TRANSFER OF BENZENE FROM MOTHER'S PLACENTA TO THE FOETUS AND THE EFFECT

本文对于苯经胎盘转运及对子代的远期影响进行了研究,结果表明:①苯可经妊娠小鼠胎盘转运造成胎仔在子宫内接触,停止接触36小时后胎仔体内仍可检出来。②胎盘对苯具有一定的屏障作用。③2000ppm染毒时胎肝血嗜多染红细胞微核出现率显著高于阴性对照组,这表明苯经胎盘转运至胎体后对胎仔体细胞有致突变作用。

By means of determination of benzene content in mice placenta and foetus, as well as the occurance of PCE micronucleus in the blood of placenta and liver, the study of the transfer of benzene through placenta and the induced mutation in foetus cells was made. The results show the possibility of transfer of benzene through placenta, depending on the toxic concentration contacted and- the period of pregnancy. In spite of placenta as a screen, yet tiny amount of benzene can be detected in the body of the foetas, 36 hours after exposure .The occurence of exposed micronucleus, 2000 ppm is apparently higher than that in control group. This suggests that concentrative benzene is able to poison the mice foetus and cause injuries in the chromosome in cells.