上海市浦东新区成人慢性肾脏病流行现状及与贫血的相关性

Epidemic situation of CKD among adults and its relationship with anemia in Pudong New Area in Shanghai

[目的]了解上海市浦东新区成人中慢性肾脏病(CKD)与贫血的流行情况,分析两者间的相关性。[方法]采用多阶段抽样方法,抽取浦东新区18岁以上社区居民3 326人,调查该人群的生活方式等基本信息,检测血肌酐、血红蛋白等指标,并作影像学检查,根据血清肌酐水平估算肾小球滤过率。[结果]浦东新区成人CKD的患病粗率为16.0%(标化率为13.2%);贫血患病粗率为1.7%。随着CKD分期增加,贫血患病率有升高趋势。CKD分期是CKD伴发贫血的独立危险因素。[结论]浦东新区成人CKD的患病率较高,CKD患者贫血患病率高于非CKD人群,且随着病情进展患病率升高。需重视社区人群CKD的筛检和预防,定期监测CKD患者及其高危人群的贫血情况,避免CKD进展和相关并发症发生。

[ Objective] To investigate the prevalence of chronic kidney disease （ CKD ） in adult residents of Pudong New Area of Shanghai and the relationship between CKD and anemia. [ Methods ] A total of 3 326 residents aged over 18 years were randomly selected and interviewed from Pudong New Area of Shanghai through multistage sampling. A fasting blood sample and a morning urine sample were collected from each participant to test plasma level of creatinine, haemoglobin and others. Glomerular filtration rate （ GFR } was calculated to estimate the renal function. [ Results] The age standardized prevalence of CKD was 13.2% , and the prevalence rate of anemia 1.7%. The prevalence rate of anemia in participants with CKD was higher than those without CKD. CKD higher stages were associated with the presence of anemia independently. [ Conclusion ] The prevalence of CKD in Pudong New Area is comparable to that previously reported in China or other developed countries. The prevalence rate of anemia among CKD patients is higher, and increases with higher stages in CKD. So a community-integrated control strategy should be warranted to prevent and monitor the incidence of ESRD and associated anemia.