摘要
In this report,a comparative study is made of the function test of spontaneousT suppressor cell（STs）and T Lymphocyte subsets in patients with epidemic hemorrha-gic fever（EHF）.It was found that in the early stages of the disease the activity of STs wasmarkedly lower than that of the controls,while the percentage of CD<sub>?</sub><sup>+</sup> cells increasedsignificantly,which led to the decrease and reciprocation of CD<sub>4</sub>/CD<sub>8</sub> ratio,and that theactivity of STs was reversely related to the proportion of CD<sub>8</sub><sup>+</sup> cells on linear regressionanalysis,indicating that the CD<sub>8</sub><sup>+</sup> cells increased may mainly belong to cytotoxic T cells.It was also shown that the changes of STs function and CD<sub>4</sub>/CD<sub>8</sub> ratio were related tothe abnormalities of serum C<sub>3</sub> content and circulating immune complex.The results sug-gest that the disturbance of host cellular immunoregulation may play an important rolein the pathogenesis of EHF.
In this report,a comparative study is made of the function test of spontaneous T suppressor cell(STs)and T Lymphocyte subsets in patients with epidemic hemorrha- gic fever(EHF).It was found that in the early stages of the disease the activity of STs was markedly lower than that of the controls,while the percentage of CD_(?)^+ cells increased significantly,which led to the decrease and reciprocation of CD_4/CD_8 ratio,and that the activity of STs was reversely related to the proportion of CD_8^+ cells on linear regression analysis,indicating that the CD_8^+ cells increased may mainly belong to cytotoxic T cells. It was also shown that the changes of STs function and CD_4/CD_8 ratio were related to the abnormalities of serum C_3 content and circulating immune complex.The results sug- gest that the disturbance of host cellular immunoregulation may play an important role in the pathogenesis of EHF.
