接触苯的氨基和硝基化合物工人安替比林及灭滴灵代谢活性的改变

Change of Antipyrine and Metronidazole Metabolic Activities in Workers Occupationally exposed to Amino and Nitro Compounds of Benzene

61名接触二硝基氯苯、硝基氯苯、二硝基甲苯及二氨基甲苯工人唾液安替比林和灭滴灵清除率明显低于对照组(62人)。表明肝微粒体酶活性被抑制。吸烟和饮酒者两药清除率增高,似可认为吸烟和饮酒是微粒体酶活性的诱导因素。血清GPT及MAO未见明显变化。血清铜蓝蛋白显著下降,而血清脂质过氧化产物MDA明显增高。作者认为,无损伤药物清除率试验以及血清铜蓝蛋白和血清MDA可望作为对接触工人进行医学监护的敏感指标。

Antipyrine and metronidazole clearanceswere studied by single sample saliva methodin workers (61) occupationally exposed to ch-loro-dinitrobenzene, chloronitrobenzene, dini-trotoluene and diaminotoluene. Some bioche-mical parameters in serum were studied si-multaneously. The antipyrine and metronida-zole clearances in exposed group were signifi-cantly less than that in control group, sugges-ting that the hepatic microsomal enzyme acti-vities may be inhibited. The antipyrine andmetronidazol clearances in smokers and drin-kers in exposed and control groups were hig-her than that in nonsmokers and nondrin-kers, respectively. Thus, smoking and drinkingmay be inducing factors of microsomal enzymeactivities, there was no difference in GPT andmonoamino oxidase (MAD) levels betweenexposed and control groups. The marked dec-reased ceruloplasmin and increased maloodial-dehyde (MDA) levels in serum were found ascompared with control group. It suggestedthat the drug clearance tests of noninvasiveassessment of microsomal enzyme activities andthe ceruloplasmin and MDA levels in serummay be used as sensitive indexes of medicalsurveillance for workers exposedto aminoand nitro compounds of benzene.