溴乙酰胺灭螺结合化疗防治血吸虫病的效果

EFFECT OF SPRAYING BROMOACETAMIDE COMBINED WITH CHEMOTHERAPY IN CONTROL OF SCHISTOSOMIASIS

山丘地区血吸虫病严重流行的2个村经过连续2年采取溴乙酰胺灭螺结合吡喹酮治疗病人、病牛后,病情、螺情和疫水感染性均迅速下降。居民粪检阳性率由31.17％降为1.87％,下降94.0％;活螺密度减少94.5％,阳性钉螺密度减少97％;哨鼠感染率由59.8％降为0.74％,平均每鼠感染虫数由5.15率降为0.015条。使用溴乙酰胺灭螺过程中未杀死鱼塘的家鱼,保护渔业的效益是显著的。

Application of a new molluscicide,bromoacetamide, by spraying method combined with treatment of infected individuals and catties with praziquentel was carried out in two villages in hilly region which was highly endemic in schistosomiasis. The effects were evaluated by camparison between the data from epidemiological surveys before and two years after the intervention. The results showed that the prevalence rate of residents dropped from 31.17 to 1.87% (reduction rate 94.0%), intensity of infection of patients from 26.1±64.1 to 10.25±0.8 EPG of stool, prevalence rate in 3-4 years(ycars) old children from 4,17% too, living snail density from 6.43 to 0.356 snail/spot (reduction rate 94.5%), infected snail density from 0.084 to 0.0025 snail / spot (reduetion rate 97.0%), infection rate of sentinel mice from 59.8 to 0.74% (reduction rate 98.8%) , and worm burden of sentinel mice from 5.15 to 0.015 per mouse(reduction rate 99.7%). There was no damage to fish by bromoacetamide spraping , therefore , the benefit for fishing in areas using bromoacetamide as a molluscicide is obvious. *WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis