杀球灵(Diclazuril)和麦杜拉霉素(Maduramycin)等四种聚醚类抗菌素对鸡巨形艾美尔球虫(E.maxima)药效的笼饲试验

EFFICACY OF DICLAZURIL AND POLYETHER ANTIBIOTICS MADURAMICIN, NARASIN, LASALOCID AND MONENSIN AGAINST E.MAXIMA IN BATTERY EXPERIMENT

对杀球灵和其它4种聚醚类抗菌素麦杜拉霉素,那拉菌素(Narasin),拉萨洛菌素(Lasalocid),莫能菌素(Monensin)的抗巨形艾美尔球虫效力进行了笼饲试验.重度感染情况下,和感染不给药对照组相比,5ppm麦杜拉霉素,80ppm那拉菌素,100ppm拉萨洛菌素和100ppm莫能菌素可防止鸡只死亡,改善增重,减轻肠道病变和减少卵囊数量.1ppm杀球灵组出现10%死亡,但是从增重和病变来看,鸡只仍然受到保护,粪便里也很少见到卵囊.对肠粘涂片的观察显示杀球灵明显抑制了巨形艾美尔球虫的有性生殖阶段,即配子生殖阶段的发育.从抗球虫指数来看,上述5种药对巨形艾美尔球虫的效力依次是拉萨洛菌素,麦杜拉霉素,杀球灵,那拉菌素和莫能菌素.

The anticoccidial efficacy of diclazuril, the newest anticoccidial drug, and other 4 polyether antibiotics against E. maxima was tested in this battery experiment. 5 ppm maduramycin, 80 ppm narasin, 100 ppm lasalocid and 100 ppm monensin well protected chickens from death, improved body weight gain, reduced intestinal lesion and oocyst count in heavy infection compared with unmedicated infected controls. With 1 ppm diclazuril, there were 10% mortality, but chickens were still protected, judged by body weight gain and intestinal lesion, and few oocysts were found in the feces. Observation of intestinal smears indicated that the sexual stage, i.e. gametogony of E. maxima was inhibited to a great degree by diclazuril.The efficacy of the 5 drugs was in the order of lasalocid, maduramicin, diclazuril, narasin and monensin judged by anticoccidial index.