同温层中臭氧耗竭对人类单核细胞免疫辅助功能的影响

Stratospheric Ozone Depletion: Immunolosic Effects on Monocyte Accessory Function in Humans

由于同温层的臭氧耗竭,预计到达地面的紫外线-B(UV-B)的辐射量将会增加,有可能对人类健康产生严重影响。最近认识到紫外线-B辐射影响的一个靶器官是免疫系统,特别是紫外线-B能使单核巨噬细胞丧失其使T淋巴细胞被同族抗原和可溶性抗原激活的能力。但有关紫外线-B对免疫功能有害影响的研究,几乎绝大部分都是用实验动物进行的。单核细胞辅助功能对细胞中介免疫的发动非常重要,本研究的目的就是要弄清紫外线-B辐射对人类单核细胞免疫辅助功能有何特殊影响。

The stratospheric ozone depletion causes the increase in the amount of ultraviolet-B radiation reaching the earth. UV-B can disrupt the human immune system and render mononuclear phagocytes deficient in their activity. The immune system plays a fundamental role in protecting individuals against noxious microorganisms and provides a surveillance mechanism against neoplastic cells as they arise. UVB-induced immune deficiencies might be expected to result in rising rates of cutaneous and possibly other malignancies, and may produce increases in the incidence of illness caused by viruses, fungi, and other microbes.