羧乙基锗倍半氧化物的抗诱变作用

STUDIES ON THE ANTfMUTAGENIC EFFECT OF CARBOXYETHYL GERMANIUM SESOUIOXIDE

羧乙基锗倍半氧化物(Ge-132)具有广泛的抗诱变作用。它对于短波紫外线(uv)诱发人胚成纤维母细胞(HEF)体外培养系统的染色体畸变(CA)和姐妹染色单体交换(SCE);对亚神酸钠诱发HEF的CA;对黄曲霉素诱发的HEF系统CA和SCE效应,以及环磷酰胺诱发小鼠活体骨髓细胞微核形成(MN)效应与CA,都呈现有剂量依赖关系的抑制作用。Ce-132的作用可能主要是抑制突变的表达,是一种有应用前景的抗诱变/抗致癌物。

Although Ge-132 has been showed to be versatile in preventive and curative medicine, reports dealt with its antimutagenicity were few.Studies attempting to verify the effectiveness and the generality of the antimutagenicity of Ge was conducted.Dose-dependent suppression on the mutageneses by it was revealed in test systems as; 1)The chromosomal aberration (CA) and sister chromatid exchange(SCE)in cultured human embryo fibroblast(HEF)induced by short wave ultraviolet ray; 2) CA in HEF induced by Na Aso; 3)CA and SCE in hepatocyte mediated HEF system induced by Aflatoxin; 4)The micronucleus in polychromatic erythrocyte and CA in bone marrow cell of mice received cyclophosphamide. Since antimutageneses of Ge were shown in different assays with various endpoints, it is likely that the underlying mechanism for mutation suppression is primary and non-specific.The perspect for using Ge in chemoprevention is encouraging and promising.