不同辐射体核素在生殖细胞滞留诱发放射遗传毒理效应研究

A COMPARATIVE STUDY ON THE RADIOGENOTOXIC EFFECT OF RETENTION OF DIFFERENT RADIOTORS IN THE MOUSE GERM CELLS

研究发现,^(147)P_m在睾丸内的滞留半减期长达10天,较难转移。而^(134)C_s的相滞留半减期只有5.2天。受^(147)P_m或^(134)C_s内污染时,均可诱发精原细胞染色体畸变,且以染色单体型畸变为主,而染色体型畸变的断片或易位则较少呈现。同时也观察到^(147)pm对初级精母细胞的遗传损伤效应,可产生染色体断片和易位,出现多价体。由于^(134)C_s在睾丸内的累积吸收剂量小于^(147)P_m,所以比较^(134)C_s所诱发的精原细胞染色体畸变和精子畸形等放射遗传毒理效应,亦明显低于^(147)P_m。

The comparison of retention of 147Pm and 134Cs in germ cell and their effects of induction of CA in spermatogonium and malformaton of sperm were studied in mice.The retention of 147Pm in testis during the period of 50 days after a single intravenous administration are: R (t) = 0.1872 × exp (- 0.0066t), where the half reduction time T1/2 = 105 d.Those of 134Cs were R (t) = 0.0045 × exp (-0.1331) and Tl/2 = 5.2 d, respectively.The uptake and retention of 147Pm is much more higher than that of 137Cs.The aberration of spermatogonium chromosome and sperm induced by 147Pm or 134Cs were resembling in pattern, e.g.gap, chromatid break, chromosome break, translocation and polyploid spermatagonium.However, the potency and time course were different.The effects induced by 147Pm were prominent and prolonged than those of 134Cs, and could be explosed by the different of uptake and retention between them.