养血补气液诱生小鼠γ-干扰素的作用及在细胞上的抗病毒能力

EFFECT OF YANG XUE BU QI YE ON THE INDUCTION OF INTERFERON IN MICE AND ITS ANTIVIRAL EFFECT IN HELA CELLS AND DIPOLID CELLS

通过对养血补气液对小鼠脾淋巴细胞诱生干扰素效果以及在Hela细胞和人胚肺二倍体细胞上的抗病毒作用的研究,结果表明不同浓度的药物所诱生干扰素的滴度与对照组比较,均有极显著性差异(P<0.01);不同浓度的药物在Hela细胞、人胚肺二倍体细胞上的抗病毒能力与对照组比较,均有显著性差异(P<0.01)。

When the concentrations of the drug Yang Xue Bu Qi Ye were 40% and 20%, the induced interferon titer were 7. 27±0. 58 respectively. It was much higher than that of the control group (4. 60±0.11u/ul). The change of antiviral titer(TCID 50)in Hela cell by various concentrations(50%,25%, 12. 5%, 6. 25%)of the drug,were 27. 57±0. 29,30. 60±0. 34, 34. 60±0. 34, 40. 50±0. 56 respectively. It was much different from that of the control (230. 80±1.18). The antiviral titer in dipolid cells were 42. 40±0. 28,46. 20±0. 54,51. 80±0. 66, 57. 89±0. 34, when the concentrations of drugs were 50%, 25%, 12. 5%, 6. 25% repectively. It was also much different from that of the control group (228. 75±0. 96). The results shows that Yang Xue Bu Qi Ye inhibits the virus reproduction in cells markedly.