六味地黄丸防止食管上皮重度增生癌变效果的观察(附211例报告)

CLINICAL OBSERVATION ON INHIBITORY EFFECT OF"LIUWEI DIHUANG" PILL(LWDH)ON SERIOUS ESOPHAGEAL EPITHELIUM PROLIFERATION(REPORT OF 211 CASES)

本文报告211例食管上皮重度增生患者服用六味地黄丸,与对照组相比,2年后癌变率分别为1.9％及8.3％,差异显著。且癌变者都发生在阴虚组中。说明六味地黄丸防止食管上皮重度增生癌变疗效显著,阴虚型的食管上皮重度增生患者癌变的危险性大。

The effect of LWDH pill on 344 patients with serious esophageal epithelium proliferation was observed clinically. Among them 211 cases were treated by LWDH pill (observed group), and 133 cases did not (control group). The rate of transformation into cancer were 1.9% and 8. 3% respectively. The difference between them was significant (X^2=7. 95, P<0.005), and suggest that the pill posseses the actions of inhibiting serious esophageal epithelium proliferation. The patients of. the control group could be differentiated into two patterns, namely, the pattern of Yin deficiency and non-Yin deficiency. The rate of transformation into cancer were 15. 2% and 4. 6% respectively (X^2=4.47, P<0. 05). This indicated that the patient with Yin deficiency is more easy to fransform into malignancy in all cases of serious esophageal epithelium proliferation.