盐酸林可霉素晶型研究

STUDY ON POLYCRYSTAUINE STATES OF LINCOMYCINI HYDROCHLORIDE

药物的多晶型对药品质量和临床药效有较大的影响,药物多晶型的研究方法有x—射线单晶结构分析,x—射线粉末法,差热分析,红外光谱分析等。影响晶型转变的因素很多,如研磨,结晶溶剂不同或改变结晶条件,所得产品晶型即有变化。本实验通过盐酸林可霉素针、片剂红外光谱测定,x—射线衍射分析,差示扫描量热法,晶型转化实验等手段,证明盐酸林可霉素为一多晶型药物,晶型之间存在互变,晶型的不同是由于精制浓度及速度不同所致,其中晶B、晶C为稳定型晶态,晶A为亚稳态晶型。

The different conditions for seperation and purification of Lindomycini Hydrochloride were studied. The Polycrystauine states of Licomycini Hynrochloride crystal A, B, C were identified by powdered X—Ray Diffration method. The crystal A is so unstable as can fe easily transformed to crystal B or crystal C.