食管中段癌单纯手术与术前放射综合治疗研究——前瞻性随机分组360例

COMBINED PREOPERATIVE IRRADIATION PLUS SURGERY VS SURGERY ALONE FOR CARCINOMA OF THE MIDTHORACIC ESOPHAGUS - A prospective randomized study on 360 patients

食管癌单纯手术或放射治疗的效果至今仍不能令人满意。为了提高食管癌的治疗效果,我院自1977年6月至1987年底对360例食管中段癌采用单纯手术与术前放疗和手术综合治疗(以下简称为综合治疗组)随机分组研究。现将结果报告如下:

360 patients with mid-thoracic esophageal carcinoma 5-8 cm in length were randomized, from 1977 through 1987, into combined group (R + S) (168 patients) and surgery group (S alone) (192 patients) . Radiation treatment was 40 Gy/20 fractions/4 wk by 8 MV-X ray. Surgery was done by ceivival or intrathoracic supraaortic anastomosis using the stomach as a substitute. The resection rates of the two groups were 89.9% (151/168) and 83.3% (160/192). The 30 day mortality rates were 3.3% (5/151) and 4.4% (7/160) .The 5 year survival rates were 36.6% (26/71) and 33.9% (19/56) (P>0.05) . There was no statistical significance in the differences between these two groups.