慢性胃溃疡癌变的临床病理探讨

THE CLINICOPATHOLOGICAL PROBE OF CANCERIZATION OF CHRONIC GASTRIC ULCER

对3441例良、恶性胃溃疡标本进行临床病理比较观察,发现其中421例恶性胃溃疡与溃疡型胃癌有明显不同,而在临床及溃疡的组织结构上与慢性胃溃疡很相似,其突出的特点为溃疡底部存在一个无癌浸润、无肌残留的疤痕区。这类溃疡的存在从临床和病理形态上支持了慢性胃溃疡癌变的事实。按综合分析的诊断标准,本组癌变率均为3.48％。

Resected specimens of benign and malignant gastric ulcers totalled 3441 cases were observed and compared clinically and pathologically. Among them 421 cases of malignant ulcer were found which differ notably from the ulcerating gastric carcinoma and have many characters like chronic gastric ulcer(CGU). Their most distinct character is without cancerous infiltration and muscular residue in the scar tissue of ulcer base. The presence of this type of ulcer clinically and pathomorphologically supports the viewpoint that CGU can become malignant. The study also revealed that the canceration rate of CGU was 3.48% according to synthetic diagnosis criterion.