小儿难治性肾病25例疗效观察与随访

REFRACTORY PRIMARY NEPHROTIC SYNDROME IN CHILDREN: A THERAPEUTIC AND FOLLOW-UP STUDY OF 25 CASES

对25例小儿难治性肾病(其中单纯型9例:肾炎型16例)应用激素中长程疗法治疗,小剂量长期维持,于激素减量时加用免疫抑制剂。同时在整个疗程中均服用中药“疫免糖浆”。经治疗及随访3年～5年,完全缓解20例,部分缓解3例,死亡1例,失访1例。认为用此法治疗小儿难治性肾病疗效较好。

25 children with refractory primary nephrotic syndrome (9 presented as pure nephrotic and 16 as nephritic nephrotic ) were treated with medium and long course of hormonotherapy combined with immunosuppressive agents as less hormones were administered. The patients were also administered Chinese medicine 'Immune Syrup' during the course of treatment. Followed up for 3-5 years, twenty cases achieved complete remission, three partial remission, one died, and one was lost. It is suggested that long course of combined therapy may improve the therapeutic effect for refractory cases.