脑胶质瘤的血清蛋白免疫组化研究

Immunohistochemical Investigation of Serum Proteins in Human Brain Gliomas

本文应用五种血清蛋白抗血清对40例脑胶质瘤石蜡切片进行PAP染色,结果显示,P-Alb和Alb在肿瘤间质内弥散存在;Cer多位于血管周围和高度间变的肿瘤细胞内;LDL和FN位于血管内及坏死组织内。本研究提示,胶质瘤中血清蛋白的类型、分布以及含量与血清蛋白的分子量、血清浓度以及肿瘤的分化程度等有关。肿瘤周围脑组织亦可见到阳性反应,表明胶质瘤时由于血脑屏障(BBB)破坏,使循环中的血清蛋白从肿瘤性血管进入肿瘤内及其周围脑组织,恶性肿瘤的BBB损害及脑水肿比良性肿瘤更为严重。

Abstract Forty cases of human brain glitimas of paraffin sections were im- munohistochemically stained for five serum proteins by the PAP method. In all gliomas P-Alb and Alb were present within the tumor interstitium. Cer was ob-served around tumor vessels and in highly anaplastic tumor consisting of poly-morphic glioma cells. LDL and FN were almost restricted to blood vessels and tu-mor necroses. These results indicate the occurrence and distribution of serum proteins in gliomas depend on serum proteins of molecular weight, serum concen-tration and differentiation of tumor. Serum, proteins accumulated in peritumoural brain tissue, in reactive astrocytes and, occasionally, in neurons, it, therefore, can be assumed that also in human brain gliomas serum proteins extravasate ma-