胆囊炎胆石症致肝纤维化的血清学诊断

Serum Diagnosis of Liver Fibrosis Caused by Cholecystitis and Cholelithiasis

本文对34名胆囊炎胆石症患者血清中Ⅲ型前胶原肽(sPⅢP)、单胺氧化酶(sMAO)及总羟脯氨酸(sTHP)的测定结果进行了分析,并与组织学肝纤维化程度进行了相关性研究。发现SPⅢP值的升高有显著差异,且与肝纤维化程度相关性良好,其诊断阳性率达72.7％,显著优于另二者。认为胆囊炎胆石症可导致肝纤维化,其程度随阻塞变化而加重;测定sPⅡP含量是一种非创伤性诊断肝纤维化敏感、可靠的方法。

It was taken of surveying and studying to the Procollagen Type Ⅲ Peptide (sPⅢP) , Monoamine Oxidase (sMAO) and Total Hydroxyproline (sTHP) in serum in 34 patients with cholecystitis and cholelithiasis, and to the relationship of the hepatic fibrosis degree. The results showed sPⅢP concentration were significantly elevated and there was a close relationship with the fibrosis degree. Its positive rate was 72.7%, significantly higher than the two others. These results suggested cholecystitis and cholelithiasis can induce hepatic fibrosis, especially in patients with obstructiva jaundice. Detecting the sPⅢP concentration is a noninvasive, sensitive and reliable method for the diagnosis of hepatic fibrosis.