角膜移植术后泪液乳铁蛋白含量测定及其临床意义初探

Lactoferrin(LF) content in tear and its clinical significance Transplantation

本文报告应用放射免疫法测定的正常人和角膜移植术后不同阶段泪液中乳铁蛋白(简称LF)含量。测定结果正常人泪液中LF的含量为2.15±0.58mg/ml;角膜移植术后2周含量下降十分显著(P<0.01),于术后4周时LF升高,术后3个月达术前水平;角膜移植术后排斥反应期间泪液LF含量明显下降(P<0.01),排斥反应治愈后LF升高,但仍低于正常水平。本文实验结果提示,泪液LF含量下降与诱发角膜移植排斥反应有关,测定泪液LF含量(可为临床治疗提供客观依据。

The LF content in the tear of 25 cases of partial penetrating keratoplasty normal persons was determined with radio-immunological method. The tear LF content in 34 healthy individuals was 2.15+0.58mg/ml(x6sd). Two weeks following the operation, there was a very significant decrease in tear LF content (p 0.01). After four weeks postoperatively it was increased, bat was still lower than that in control group three months. It reteurned to pre-operative level after operation, the tear LF content was decrease in the period of rejection after keratoplasty. These results showed that there was a relationship between the LF contents and corneal graft rejection.