江浙蝮蛇抗栓酶对肾病综合征患者血浆组织型纤溶酶原激活剂及其抑制物的影响

EFFECT OF SVATE ON PLASMA IEVELS OF T■SSUE ■IASMI■OGEN ACTIVAIOR AND ITS INHIBITOR IN NEPHROTIC SYNDROME

本文观察了江浙蝮蛇抗栓酶(Svate)对肾病综合征(NS)患者血浆组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性的影响。结果示:Svate治疗后血浆PAI活性明显降低,tPA活性轻度升高。提示Svate可能通过影响tPA及PAI而改善NS患者的纤溶状态。

Svate is a kind of new drug separated from the venom of AgkistrodonHalys of Jangsu and Zhejang provinces. Ten patients with nephrotic syndromewere theated with Svate in this paper and the plasma levels of tissue plasminogenactivator (tPA) and plasminogen activator inhibitor (PAI)were observed beforeand after the treatment. The results showed that there were decreased levels ofPAI and increased that of tPA after the treatment of Svate, which suggestedthat Svate might be valuable in the improvement of the fibrinolytic state inthe nephrotic syndrome.