阴离子间隙在儿科疾患中的分析与应用

Analysis and Application of Anion Gap in Different Diseases in Childhood

阴离子间隙(AG)是近年来应用于临床的评价酸碱紊乱的重要指标。本文应用微电脑分析了170例儿科患儿的 AG 及其与血清电解质之关系,结果显示:39.9%的患儿 AG 在正常范围,平均 AG 为11.07mmol/L,52.1%呈 AG 增高,平均 AG 为20.99-mmol/LAG 降低占8%,平均 AG 为4.11mmol/L;AG 正常者,AG 与钠呈正相关,与碳酸氢盐呈负相关;AG 增高时,与钠、钾、氯、碳酸氢盐均呈负相关;AG 降低者中有69.2%出现高血氯。本文结果还表明,代谢性酸中毒者有63.8%AG 增高,AG 无增高者主要是由于高氯、低钠所致;AG 增高者中有70.6%为临床诊断有代谢性酸中毒。并提出 AG 增高可作为代谢性酸中毒的诊断指标,尤其是当 AG>25mmol/L 时,诊断更为可靠。本文还分析了婴儿腹泻、支肺炎等儿科常见病患儿的 AG 及血清电解质情况。

Anion gap(AG)is an important index for estimating acide-base equilibrium. Using the private computer,we have analysed the AG of 170 children with different diseases.The result showed that 39.9% of the patients had normal levels of AG,the average AG was 11.07 mmol/ L.And 52.1% had increased levels of AG,the average AG was 20.99mmol/L.We observed that AG was positively correlated to serum sodium and negatively correlated to serum bicabonate when the AG level was normal.The AG was negatively correlated to serum sodium,potassium, chloride and bicarbonate.This paper also shows 63.8% of patients with metabolic acidosis had in- creased levels of AG;70.6% of patients with increased levels of AG were diagnosed as metabolic acidosis.