儿茶酚胺能神经在慢性一肾Grollman高血压中的作用

Role of Catecholaminergie Nerves in Chronic One—Kidney Grollman Hypertension

本文研究了儿茶酚胺(CA)能神经在大鼠慢性一肾 Grollman 高血压中的作用。结果显示,手术后12周高血压大鼠下丘脑后部、延脑、心脏、血管、肾上腺及血浆中去甲肾上腺素(NE)、肾上腺素(E)的含量明显高于正常血压大鼠;用6-OHDA 损毁高血压大鼠中枢 CA 能神经后,血压和上述组织中 NE、E 以及脑内血管紧张素Ⅱ(AⅡ)的浓度均明显降低。提示(1)中枢 CA 能神经和外周交感神经在大鼠慢性一肾 Grollman 高血压中可能起重要作用,(2)中枢 CA 能神经可能至少通过激活外周交感神经、肾上腺髓质和影响脑内肾素-血管紧张素系统的活动而参与高血压的维持机制。

The role of catecholaminergic nerves was investigated in the rats with chronic one-kidney Grollman hypertension.The results showed that thenore- pinephrine(NE)and epinephrine(E)contents in the posterior hypothalamus, medulla oblongata,heart,vessel,adrenal gland and plasma of the hypertensive rats were all significantly higher than that of the normotensive rats at the 12th week after operation.After the central catecholaminergic nerves of the hypertensive rats were destroyed by 6 hydroxydopamine(6-OHDA),the blood presure and the NE and E contents in the above tissues were all markedly lower than that of the hypertensive rats receiving vehicle,and the angiotensin 11 content in the above two brain regions was also apparently decreased.These results suggest that(1)the central catecholaminergic and peripheral sympathetic nerves probably play an important role in the rats with chronic one-kidney Grollman hypercension,(2)the central catecholaminergic nerves may parti- cipate in the hypertensive maintenance at least through activiting peripheral sympathetic nerves and adrenal medulla,and affect the activities of the renin- angiotensin-system in the brain.