肺癌的危险因素及其相对危险度与归因危险度估计

ESTIMATING THE RELATIVE RISK AND ATTRIBUTABLE RISK OF SELECTED RISK FACTORS FOR LUNG CANCER

本文报道了1986年至1988年南京市城区原发性肺癌的配对病例对照研究。共收集病例91人,以1:1选择对照。条件Logistic回归模型拟合结果表明,吸烟、肺癌家族史、其它肿瘤家族史和烹调油烟是肺癌发生的危险因素,其相对危险度分别为1.8613、6.5215、5.0133和2.5504,人群归因危险度分别为49.45％、13.03％、19.35％和41.42％。四项危险因素的综合人群归因危险度为79.59％,即若消除该四项危险因素,肺癌的发生可减少79.59％。本研究结果可为制定肺癌的防制对策提供依据。

This paper reports the results of analysing 1:1 matched case-control data of lung cancer using Logistic regression model.Ninety-one cases were from the urburn districts in Nanjing during 1986-1988. Smoking, smoke from oil in kitchen when cooking and family history of lung cancer and other tumors are selected as the risk factors of lung cancer. The relative risk tand population attributable risk of these significant factors are 1.8613, 2.5304, 6.5215,and 5.0133,and 49.45％, 41.42％, 13.03％ and 19.35％,respectively. General population attributable risk of the four factors is 79.59％. The result provides an evidence for choosing preventive strategies of lung cancer.