葛根素治疗抗结核药物性肝炎临床观察

Effect of puerarin on liver injury induced by anti-tuberculosis drugs

目的探讨观察葛根素注射液对抗结核药物性肝炎的临床治疗作用。方法将120例抗结核药物性肝炎结核病患者随机分成治疗组和对照组各60例,在接受抗结核治疗的基础上,治疗组在基础治疗中加用注射用葛根素注射液静脉滴注,对照组给予还原型谷胱甘肽进行护肝治疗。结果治疗组和对照组治疗后肝功各项指标均显著改善,与治疗前比较差异均有统计学意义,且两组间各项指标差异无统计学意义。结论葛根素注射液可以有效地治疗抗结核药所致的肝损害,其效果与还原型谷胱甘肽相当。

Objective To investigate the effect of puerarin on liver injury induced by anti-tuberculosis drugs.Methods One hundred and twenty patients were randomly assigned into two groups,the control group treated with reductive glutathion and the treatment group administrated with puerarin,with 60 patients in each.In this period,the basic anti-tuberculosis treatment was given as before.Results All the liver injury indexes were significantly improved after treatments in both groups,however,these indexes showed no significant difference between two groups.Conclusion Puerarin is an effective treatment on liver injury induced by anti-tuberculosis drugs,which is as powerful as reductive glutathion.