脂联素与心血管疾病的研究现状与展望

The Current Situation and Prospect of Adiponectin and Cardiovascular Disease

肥胖与心血管疾病及代谢紊乱密切相关。脂联素是一种脂肪源性血浆蛋白,在与肥胖相关的代谢紊乱及疾病中含量降低,低脂联素水平与肥胖相关的心血管疾病危险性增加有关。有研究表明,脂联素可直接作用于心肌及血管细胞发挥作用,可通过多种机制保护心血管系统。其中主要包括调节一磷酸腺苷活性蛋白酶介导的信号通路、抑制炎症与促进内皮细胞功能等。脂联素所共有的调节代谢、抗炎及血管保护、心肌保护作用,可为临床治疗代谢综合征性心血管疾病,提供新的干预靶点和治疗思路。

Adiposity is strongly associated with metabolic and cardiovascular disorders.Adiponectin is an adipose-derived plasma protein that is downregulated in subjects with obesity-related disorders.Low levels of adiponectin are associated with the increased prevalence of adiposity-linked cardiovascular diseases.Experimental findings have shown that adiponectin has beneficial effects in the cardiovascular system by directly acting on the component cells of the heart and blood vessels.Adiponectin protects cardiovascular tissues through a number of mechanisms including inhibition of inflammatory and hypertrophic responses,and stimulation of endothelial cell responses.The effects of adiponectin have been attributed to the modulation of signaling molecules about AMP-activated protein kinase.Owing to the effects of metabolic regulation,anti-inflammation,and protection of cardiovascular tissues,adiponectin could be a promising therapeutic target for cardiovascular diseases and metabolic syndromes.