急性冠状动脉综合征标志物预测价值的新进展

New Progress in Predictive Value of Acute Coronary Syndrome Markers

急性冠状动脉综合征(ACS)的发生多是在不稳定斑块出现裂缝、糜烂或破裂的基础上,形成血栓,导致急性心肌缺血。因其发病急,常导致严重心脏事件而受到特别关注。目前认为,ACS的发病基础取决于斑块的稳定性而不是动脉管腔狭窄的严重程度。寻求新型敏感的特异性的斑块不稳定性标志物比传统的危险因子能够更好的预测ACS,如红细胞膜胆固醇、基质金属蛋白酶及髓过氧化物酶,对ACS的危险分层及治疗均有重要的意义。

Most acute coronary syndromes（ACS） are caused by thromboses occurring over unstable plaques on the basis of crack,debaucjed or rupture,than cause acute myocardial ischemia.ACS requires particular attention because of its morbidity and the prevalence with which it leads to serious cardiac events.At present the basic pathogenesis of ACS depends on the stability of the arterial plaque rather than the severity of luminal stenosis.Seeking out sensitive and specific plaque instability is better for predicting acute coronary syndrome than traditional risk factors like CEM,MMP and MPO.